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Online learning and teaching, accelerated by the global pandemic and rapid advancement of digital technology, require novel conceptual and analytical tools to understand better the evolving nature of online teaching. Drawing on the classical model of the instructional triangle and previous attempts to extend it, we propose theInstructional Technology Tetrahedron(ITT)—a conceptual framework that integrates technology into the instructional triangle to represent the role of technology, as a learning tool and a mediator between teachers, students, and content. Combining the ITT framework with network visualization strategies allowed for representing the intensity of interactions within the tetrahedron. We illustrate the affordances of the ITT framework by analyzing reflective noticing patterns of three prospective secondary teachers (PSTs) who reflected on the video recordings of their own online teaching, with each PST teaching four online lessons to groups of high-school students. We demonstrate the utility of the ITT framework to characterize individual noticing patterns, in a particular lesson and across time, and to support a variety of cross-case comparisons. The discussion sheds light on the broader implications of the ITT framework. 

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.